Move, leptin. Researchers have discovered another fat hormone that can help in promoting weight loss. A new study suggests that hormonal adiponectin, which is found in adipose tissue, can cause weight loss, boosting metabolism without affecting appetite. Researchers say the discovery can lead to better treatments for obesity and other metabolic disorders such as diabetes. Leptin, a related fat hormone, has been widely studied in recent years and has been shown to produce weight loss in animals by decreasing appetite and increased metabolism. Researchers say both fatty hormones work through the same path in the brain to control body weight and blood sugar (glucose). But these hormones can also control metabolism, although other unique forms, and learning more about how they work can lead to more effective anti-obesity treatments.
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Fat hormone increases metabolism In the study, published in the April issue of Nature Medicine, researchers injected adiponectin into normal laboratory mice. They found that mice lost weight, although the hormone did not seem to change the appetite or cause changes in the amount of food that rats ate. "The animal burns more calories, then with time loses weight, which was very fascinating because we knew that leptin caused weight loss, suppressing the appetite and increasing the metabolic rate," says researcher Rexford AHIMA, MD, PHD, Assistant Professor of Medicine at the University of Pennsylvania, in a news version. "Here we have another fat hormone that can cause weight loss, but without affecting ingestion." Researchers say that fatty hormones such as leptin and adiponectin are of interest because they can help promote long-term weight loss. Over time, weight loss becomes more difficult because the body compensates, in part, decreasing its metabolic rate - the rate in which it burns calories. If drugs can be developed that capitalize the properties of increased metabolism of these fat hormones, they may be able to sustain weight loss efforts over a long period of time without adverse health effects. "Adiponectin or its targets in the brain and other organs could be used to sustain weight loss while maintaining a high metabolic rate", ways ahima. "This is just a possibility. We are not suggesting at that point that Adiponectin will become a drug."
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